If you have some free time (about half an hour or so), you should try this. The Penny Arcade guys have been putting together a Podcast of the comic creation. The one I just listened to is pretty funny, If you're on the Gabe/Tycho wavelength. But whats really cool is they actually hammer out the comic on the podcast. So I listened to the 'cast with the comic in question in view. And you can sense the design coming together.
Ok, it appeals to the wannabe in me.
This comic and this podcast are what you need to try it.
(Oh, uncharacteristic so NSFW, btw.)